Vol. 18 No. 2 (2019)
Original Articles

Prevalence of sickle cell trait in blood donors: A systematic review

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  • Letícia A. F. Machado,
  • Edney G. da C. Gomes,
  • Lívia C. de Oliveira,
  • Larissa C. Lima,
  • José F. N. Neto
Letícia A. F. Machado
Professional Master’s in Health. Medicine Laboratory and Forensic Technology. Rio de Janeiro State University. Rio de Janeiro, RJ, Brazil
Edney G. da C. Gomes
Professional Master’s in Health. Medicine Laboratory and Forensic Technology. Rio de Janeiro State University. Rio de Janeiro, RJ, Brazil
Lívia C. de Oliveira
Search Group NutriPali. Nutritionist Palliative Care Unit, National Cancer Institute José Alencar Gomes da Silva (INCA). Rio de Janeiro, RJ, Brazil.
Larissa C. Lima
Search Group NutriPali. Nutritionist Palliative Care Unit, National Cancer Institute José Alencar Gomes da Silva (INCA). Rio de Janeiro, RJ, Brazil.
José F. N. Neto
Lipids Laboratory-LabLip, Faculty of Medical Sciences. Rio de Janeiro State University. Rio de Janeiro, RJ, Brazil.
DOI: https://doi.org/10.12957/bjhbs.2019.53498

Published 2020-01-03

Keywords

  • Sickle cell trait,
  • Blood donor,
  • Blood transfusion

How to Cite

1.
Letícia A. F. Machado, Edney G. da C. Gomes, Lívia C. de Oliveira, Larissa C. Lima, José F. N. Neto. Prevalence of sickle cell trait in blood donors: A systematic review. BJHBS [Internet]. 2020 Jan. 3 [cited 2024 Oct. 11];18(2):95-102. Available from: https://bjhbs.hupe.uerj.br/bjhbs/article/view/117

Copyright (c) 2020 Brazilian Journal of Health and Biomedical Sciences

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Abstract

Introduction: The sickle cell trait is a genetic mutation characterized by the presence of hemoglobin S (HbS) in heterozygosis in which patients are asymptomatic, which makes them suitable for blood donation. Aim: Systematizing data related to the prevalence of the sickle cell trait among blood donors. Materials and methods: A search of the literature was conducted in May 2019 to seek articles published from 1990 and which had available online abstracts, in four electronic databases. Studies were selected with the following characteristics: (1) original work; (2) observational; (3) developed with blood donors; and (4) showing prevalence of sickle cell trait. Two independent reviewers identified the articles for inclusion in this systematic review of the literature (SRL), extracted the pre-determined data and carried out the evaluation of the works’ methodological quality. Results: Eight studies published in the last 12 years in different countries were selected to take part in this SRL. With variable sample size, all presented a cross-sectional methodology. For the detection of the presence of HbS, electrophoresis in alkaline pH was commonly used. The statistical analysis developed involved simple techniques, showing that the prevalence of blood donors with sickle cell trait ranged from 0.4% to 20.8%. The majority of studies was considered of high methodological quality. Conclusion: The prevalence of sickle cell trait among blood donors varies widely, although it may not be moderate, given that the screening of HbS has important clinical significance for the proper use of this blood component.

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