Vol. 22 No. 2 (2023)
Literature Review

Prevalence of vitamin D deficiency in children with sickle cell anemia: a systematic review

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  • Isabela G. Bristotte,
  • Natália V. S. Daniel,
  • Luciana Pietro
Isabela G. Bristotte
Curso de Nutrição da Universidade Paulista. Universidade Paulista. Campinas, SP, Brasil.
Natália V. S. Daniel
Instituto de Ciências e Saúde (ICS), Universidade Paulista. Campinas, SP, Brasil.
Luciana Pietro
Instituto de Ciências e Saúde (ICS), Universidade Paulista. Campinas, SP, Brasil.
DOI: https://doi.org/10.12957/bjhbs.2023.80047

Published 2023-12-20

Keywords

  • Sickle Cell Anemia,
  • Nutritional Status,
  • Children,
  • Vitamin D

How to Cite

1.
Isabela G. Bristotte, Natália V. S. Daniel, Luciana Pietro. Prevalence of vitamin D deficiency in children with sickle cell anemia: a systematic review. BJHBS [Internet]. 2023 Dec. 20 [cited 2024 Apr. 27];22(2). Available from: https://bjhbs.hupe.uerj.br/bjhbs/article/view/153

Copyright (c) 2023 Brazilian Journal of Health and Biomedical Sciences

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Abstract

Sickle cell anemia is a genetic disease that is highly prevalent in the Brazilian population, especially among black ethnic groups descended from migration of enslaved people from Africa, as well as descendants from the process of miscegenation. The disease is a clinical expression of the homozygosity of the hemoglobin S gene, which may be of genetic and/or hereditary origin, and is caused by the replacement of the normal residue of glutamic acid with the amino acid valine in the sixth position of the polypeptide chains of the beta-globin protein. This process generates biochemical alterations in hemoglobin S molecules that polymerize inside the erythrocyte and transform into sickle cells. Lack of vitamin D may possibly be linked to disease processes, as well as to individuals’ pain crises. Objectives: To conduct a systematic review in order to analyze the prevalence of vitamin D deficiency in children with sickle cell anemia. Methodology: A systematic review was carried out by means of a search for original articles in the English and Portuguese languages in the following scientific databases: Pubmed, Science Direct, Lilacs and Scielo. Results: Among 10 articles found, 8 showed a prevalence of vitamin D deficiency (<20 ng/ml) in children with sickle cell anemia. Conclusion: The prevalence of vitamin D deficiency was high in patients with sickle cell disease, so supplementation of this substance may be helpful in treatments to improve the condition and in preventing deficiency. However, further studies that target this association and/or intervention are required to obtain more practical results. 

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