Vol. 22 No. 2 (2023)
Literature Review

Prevalence of vitamin D deficiency in children with sickle cell anemia: a systematic review

pdf
  • Isabela G. Bristotte,
  • Natália V. S. Daniel,
  • Luciana Pietro
Isabela G. Bristotte
Curso de Nutrição da Universidade Paulista. Universidade Paulista. Campinas, SP, Brasil.
Natália V. S. Daniel
Instituto de Ciências e Saúde (ICS), Universidade Paulista. Campinas, SP, Brasil.
Luciana Pietro
Instituto de Ciências e Saúde (ICS), Universidade Paulista. Campinas, SP, Brasil.
DOI: https://doi.org/10.12957/bjhbs.2023.80047

Published 2023-12-20

Keywords

  • Sickle Cell Anemia,
  • Nutritional Status,
  • Children,
  • Vitamin D

How to Cite

1.
Isabela G. Bristotte, Natália V. S. Daniel, Luciana Pietro. Prevalence of vitamin D deficiency in children with sickle cell anemia: a systematic review. BJHBS [Internet]. 2023 Dec. 20 [cited 2025 Jan. 22];22(2). Available from: https://bjhbs.hupe.uerj.br/bjhbs/article/view/153

Copyright (c) 2023 Brazilian Journal of Health and Biomedical Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Crossref
Scopus
Google Scholar
Europe PMC

Abstract

Sickle cell anemia is a genetic disease that is highly prevalent in the Brazilian population, especially among black ethnic groups descended from migration of enslaved people from Africa, as well as descendants from the process of miscegenation. The disease is a clinical expression of the homozygosity of the hemoglobin S gene, which may be of genetic and/or hereditary origin, and is caused by the replacement of the normal residue of glutamic acid with the amino acid valine in the sixth position of the polypeptide chains of the beta-globin protein. This process generates biochemical alterations in hemoglobin S molecules that polymerize inside the erythrocyte and transform into sickle cells. Lack of vitamin D may possibly be linked to disease processes, as well as to individuals’ pain crises. Objectives: To conduct a systematic review in order to analyze the prevalence of vitamin D deficiency in children with sickle cell anemia. Methodology: A systematic review was carried out by means of a search for original articles in the English and Portuguese languages in the following scientific databases: Pubmed, Science Direct, Lilacs and Scielo. Results: Among 10 articles found, 8 showed a prevalence of vitamin D deficiency (<20 ng/ml) in children with sickle cell anemia. Conclusion: The prevalence of vitamin D deficiency was high in patients with sickle cell disease, so supplementation of this substance may be helpful in treatments to improve the condition and in preventing deficiency. However, further studies that target this association and/or intervention are required to obtain more practical results. 

pdf

Metrics

Metrics Loading ...

References

  1. Araújo ACT; Campos JADB. Subsidies to evaluate the nutritional status in children and adolescents by anthropometric indicator. Alim. Nutr., Araraquara, v.19, n.2, p.219-225, abr./jun. 2008. ISSN 0103-4235
  2. Mataratzis PSR, Accioly E, Padilha P de C. Deficiências de micronutrientes em crianças e adolescentes com anemia falciforme: uma revisão sistemática. Rev. Bras. Hemat. Hemot [Internet]. 2010 [cited 2021 Jun 2];32(3):247–56. Available from: https://www.scielo.br/j/rbhh/a/CvFYChTMMr9wNDkJnWCGdkK/?format=pdf&lang=pt. https://doi.org/10.1590/S1516-84842010005000078
  3. Mota FM, Ferreira Júnior MA, Cardoso AIQ, et al. Analysis of the temporal trend of mortality from sickle cell anemia in Brazil. Rev Bras Enferm. 2022;75(4):e20210640. https://doi.org/10.1590/0034-7167-2021-0640
  4. Mendonça AC; Garcia JL; Almeida CM; et al. Muito além do “Teste do Pezinho”. Rev. Bras. Hemat. Hemot. Abril 2009;31(2): 88-93. . https://doi.org/10.1590/S1516-84842009005000012
  5. Hankins J. Toward high quality medical care for sickle cell disease: are we there yet? Jornal de Pediatria. 2010 Aug 11;86(4). doi:10.2223/JPED.2021
  6. Leão LL, Aguiar MJB de. Newborn screening: what pediatricians should know. Jornal de Pediatria. 2008 Sep 29;84(7):80-90.doi:10.2223/JPED.1790
  7. Guimarães CTL; Coelho GO. A importância do aconselhamento genético na anemia falciforme. Ciência & Saúde Coletiva, [s.l.], jun. 2010; 15(1):1733-40, ISSN: 1678-4561
  8. Salles C, Bispo M, Trindade-Ramos RT. Association between morphometric variables and nocturnal desaturation in sickle-cell anemia. Jornal de Pediatria. 2014 Jul;90(4):420–5. https://doi.org/10.1016/j.jped.2014.01.005
  9. Rodrigues MJ; Menezes VA; Luna ACA. Saúde bucal em portadores da anemia falciforme (Oral health in patients with cell anemia). Revista Gaúcha Odontol.,Porto Alegre, v.61, suplemento 0, p. 505-510, jul./dez., 2013. On-line ISSN 1981-8637
  10. Castro LCG. O sistema endocrinológico vitamina D. Arquivos Brasileiros de Endocrinologia & Metabologia [Internet]. 2011 Nov;55(8):566–75. Available from: https://europepmc.org/abstract/med/22218438 https://doi.org/10.1590/S0004-27302011000800010
  11. Alves M; Bastos M; Leitão F; et al. Vitamina D–importância da avaliação laboratorial. Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo, [s.l.], v. 8, n. 1, p.32-39, jan. 2013. https://doi.org/10.1016/j.rpedm.2012.12.001
  12. Nolan VG; Nottage KA; Cole EW; et al. Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review. Plos One, [s.l.], v. 10, n. 3, p.0119908, 3 mar. 2015. doi: 10.1371/journal.pone.0119908
  13. Oliveira JF; Vicente OG; Santos JPP; et al. Vitamina D em crianças e adolescentes com doença falciforme: uma revisão integrativa. Revista Paulista de Pediatria, [s.l.], v. 33, n. 3, p.349-354, set. 2015. https://doi.org/10.1016/j.rpped.2014.09.008
  14. Soe HHK; Abas AB; Than NN; et al. Vitamin D supplementation for sickle cell disease. Cochrane Database of Systematic Reviews, [s.l.], p.1-32, 20 jan. 2017. doi: 10.1002/14651858.CD010858.pub2
  15. Adegoke SA; Smith OS; Adekile AD; et al. Relationship between serum 25-hydroxyvitamin D and inflammatory cytokines in paediatric sickle cell disease. Cytokine, [s.l.], v. 96, p.87-93, ago. 2017. https://doi.org/10.1016/j.cyto.2017.03.010
  16. Arya SC; Agarwal N. Apropos “Complete Resolution of Sickle Cell Chronic Pain With High-dose Vitamin D Therapy. Journal Of Pediatric Hematology/oncology, [s.l.], v. 34, n. 4, p.172-173, maio 2012. doi: 10.1097/MPH.0b013e31821ed3ea.
  17. Aljama A; Alkhalifah M; Al-Dabbous A; et al Deficiência de vitamina D em pacientes com doença falciforme na Província Oriental da Arábia Saudita. Ann Saudi Med, 2018; 38 (2): 130-136. https://doi.org/10.5144/0256-4947.2018.130
  18. Jackson TC; Krauss MJ; Debaun MR.; et al. Vitamin D Deficiency and Comorbidities in Children with Sickle Cell Anemia. Pediatric Hematology and Oncology, [s.l.], v. 29, n. 3, p.261-266, 30 mar. 2012. doi: 10.3109/08880018.2012.661034.
  19. Rovner AJ.; Stallings VA.; kawchak DA.; et al. High Risk of Vitamin D Deficiency in Children with Sickle Cell Disease. J Am Diet Assoc, [s.l.], v. 108, n. 9, p.1512-1516, set. 2008. DOI: 10.1016/j.jada.2008.06.433
  20. Wykes C; Arasaretnam A; O’driscoll S; et al. Vitamin D deficiency and its correction in children with sickle cell anaemia. Annals Of Hematology, [s.l.], v. 93, n. 12, p.2051-2056, 2 jul. 2014. doi: 10.1007/s00277-014-2144-7
  21. Garrido C.; Cela E.; Beléndez C.; et al. Status of vitamin D in children with sickle cell disease living in Madrid, Spain. European Journal of Pediatrics, [s.l.], v. 171, n. 12, p.1793-1798, 5 set. 2012. doi: 10.1007/s00431-012-1817-2.
  22. Adegoke SA; Oyelami OA; Adekile A; et al. Influence of serum 25-hydroxyvitamin D on the rate of pain episodes in Nigerian children with sickle cell anaemia. Pediatrics And International Child Health, [s.l.], v. 37, n. 3, p.217-221, 8 mar. 2017. DOI: 10.1080/20469047.2017.1295012
  23. Adegoke SA; Braga JAP; Adekile AD; et al. The Association of Serum 25- Hydroxyvitamin D With Biomarkers of Hemolysis in Pediatric Patients with Sickle Cell Disease. Journal of Pediatric Hematology/Oncology, 40 (2), 159-162. 2018. doi: 10.1097/MPH.0000000000000783.
  24. Lee MT; Licursi M.; Mcmahon DJ. Vitamin D deficiency and acute vaso-occlusive complications in children with sickle cell disease. Pediatric Blood & Cancer, [s.l.], v. 62, n. 4, p.643-647, 13 jan. 2015. doi: 10.1002/pbc.25399.
  25. Osunkwo I; Hodgman EI; Cherry K; et ale. Vitamin D deficiency and chronic pain in sickle cell disease. Br J Haematol 2011; 153:538-40. https://doi.org/10.1111/j.1365-2141.2010.08458.x
  26. Shams T; Wadani HA; El-Masry R; et al. Effect of prophylactic vitamin D on anesthetic outcome in children with sickle cell disease. Journal of Anaesthesiology Clinical Pharmacology. 2014;30(1):20. doi: 10.4103/0970-9185.125692.
  27. Buison AM.; Kawchak DA.; Schall J.; et al. Low vitamin D status in children with sickle cell disease. The Journal of Pediatrics, 145 (5), 622–627. 2004. doi: 10.1016/j.jpeds.2004.06.055
  28. Carneiro ARCP; Pádua CS; Freire TT; et al. Perfil nutricional de pacientes pediátricos com anemia falciforme no estado do acre no período de outubro a dezembro de 2016. South American Journal of Basic Education, Technical and Technological, v. 5, n. 1, 2018. ISSN: 2446-4821
  29. Ministério da Saúde. Protocolo Clínico e Diretrizes Terapêuticas Doença Falciforme – Relatório de Recomendação, nº 312, 2018.
  30. Martins PRJ.; Moraes-Souza H; Silveira TB. Morbimortalidade em doença falciforme. Revista Brasileira de Hematologia e Hemoterapia, [s.l.], v. 32, n. 5, p.378-383, 2010. https://doi.org/10.1590/S1516-84842010000500010
  31. Holick MF; Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008;87(suppl):1080S– 6S. https://doi.org/10.1093/ajcn/87.4.1080S