Vol. 23 No. 2 (2024)
Literature Review

The advent of Paracoccidioidomycosis Ceti and new views on Lacaziosis

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  • Rodrigo Siqueira-Batista,
  • Fernanda M. Hammer,
  • Isabela S. Brito,
  • Gabriela S. Carvalho,
  • Jorge Luiz D. Gazineo,
  • Marli do C. Cupertino,
  • Renato N. Feio,
  • Salvatore Siciliano
Rodrigo Siqueira-Batista
Universidade Federal de Viçosa
Bio
Fernanda M. Hammer
Escola de Medicina, Faculdade Dinâmica do Vale do Piranga. Ponte Nova, MG, Brazil.
Isabela S. Brito
Bio
Gabriela S. Carvalho
Bio
Jorge Luiz D. Gazineo
Serviço de Doenças Infecciosas e Parasitárias, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brazil.
Marli do C. Cupertino
Faculdade de Medicina, Faculdade Dinâmica do Vale do Piranga. Ponte Nova, MG, Brazil.
Renato N. Feio
Departamento de Biologia Animal, Universidade Federal de Viçosa. Viçosa, MG, Brazil.
Salvatore Siciliano
Departamento de Ciências Biológicas, Escola Nacional de Saúde Pública Sérgio. Escola Nacional de Saúde Pública Sérgio Arouca, Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.
DOI: https://doi.org/10.12957/bjhbs.2024.88701

Published 2024-12-20

Keywords

  • Lacaziosis,
  • Lacazia loboi,
  • Paracoccidioidomycosis ceti

How to Cite

1.
Siqueira-Batista R, Hammer F, Silva Brito I, Souza Carvalho G, Dutra Gazineo JL, do Carmo Cupertino M, Neves Feio R, Siciliano S. The advent of Paracoccidioidomycosis Ceti and new views on Lacaziosis. BJHBS [Internet]. 2024 Dec. 20 [cited 2025 Jan. 22];23(2). Available from: https://bjhbs.hupe.uerj.br/bjhbs/article/view/174

Copyright (c) 2024 Brazilian Journal of Health and Biomedical Sciences

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Abstract

The disease caused by the fungus Lacazia loboi – called lacaziosis – is an uncommon morbid condition that produces skin lesions in humans. Since its formal description in the 1930s, the disease continues to be investigated, especially for a better characterization of the etiological, diagnostic, and therapeutic aspects. Added to the list of doubts that have hovered over the decades about lacaziosis, the possibility of involvement of cetaceans, which have lesions like those described in Homo sapiens. The debate about the etiology of the proliferative verrucous cutaneous lesions caused by non-cultivable yeast reported in dolphin was almost completely solved in recent years, as all the evidence pointed that the etiological agent belongs to the genus Paracoccidioides.  There is no molecular evidence of the infection by Lacazia loboi in cetaceans. Based on these preliminary considerations, the objectives of the present article are (1) to review the main etiological, pathogenic, clinical, diagnostic, therapeutic and ecoepidemiological findings of human lacaziosis and (2) to present the most important aspects of the ceti PCM of aquatic mammals.

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