Vol. 21 No. 2 (2022)
Clinical Cases

Metastatic prostate cancer with negative MRI-targeted prostate biopsies: case report

Published 2023-01-03

Keywords

  • Prostate Neoplasms,
  • Image-Guided Biopsy,
  • Positron Emission Tomography combined with Computed Tomography,
  • Carcinoma of unknown primary

How to Cite

1.
S. Diniz V, M. C. Lara C, Damião R. Metastatic prostate cancer with negative MRI-targeted prostate biopsies: case report. BJHBS [Internet]. 2023 Jan. 3 [cited 2024 Nov. 7];21(2):156-60. Available from: https://bjhbs.hupe.uerj.br/bjhbs/article/view/18

Abstract

This article presents the case of an asymptomatic patient with ascending PSA and suspected prostate cancer, who underwent two MRI-targeted prostate biopsies, both of which were negative for this neoplasm. PSMA PET/CT revealed secondary bone implant, while the biopsy of the metastatic lesion showed prostate adenocarcinoma. Docetaxel-based chemotherapy associated with androgen deprivation was performed. Despite the high accuracy of MRI-targeted prostate biopsy, diagnosis can occasionally be difficult, and PSMA PET/CT can help to detect distant lesions and aid the diagnosis.

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References

  1. EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam 2022. ISBN 978-94-92671-16-5.
  2. Rassy E, Pavlidis N. The currently declining incidence of cancer of unknown primary. Cancer Epidemiol. 2019;61:139. doi: 10.1016/j.canep.2019.06.006.
  3. Katagiri H, Takahashi M, Inagaki J, et al. Determining the site of the primary cancer in patients with skeletal metastasis of unknown origin: a retrospective study. Cancer. 1999;86(3):533. doi: 10.1002/(sici)1097-0142(19990801)86:3<533::aid-cncr24>3.0.co;2-1.
  4. Brazilian Society of Urology. Counseling for the early diagnosis of prostate cancer. 2020 Oct 10. Available from: https://portaldaurologia.org.br/medicos/noticias/aconselhamento-para-o-diagnostico-precoce-do-cancer-de-prostata/
  5. Kasivisvanathan V, Rannikko AS, Borghi M, et al. MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis. N Engl J Med. 2018;378:1767. doi: 10.1056/NEJMoa1801993. Epub 2018 Mar 18.
  6. van der Leest M, Cornel E, Israel B, et al. Head-to-head Comparison of Transrectal Ultrasound-guided Prostate Biopsy Versus Multiparametric Prostate Resonance Imaging with Subsequent Magnetic Resonanceguided Biopsy in Biopsy-naive Men with Elevated Prostate-specific Antigen: A Large Prospective Multicenter Clinical Study. Eur Urol. 2019;75:570. doi: 10.1016/j.eururo.2018.11.023
  7. Bryk, DJ, Llukani E, Taneja SS, et al. The Role of Ipsilateral and Contralateral Transrectal Ultrasound-guided Systematic Prostate Biopsy in Men With Unilateral Magnetic Resonance Imaging Lesion Undergoing Magnetic Resonance Imaging-ultrasound Fusion-targeted Prostate Biopsy. Urology. 2017;102:178. doi: 10.1016/j.urology.2016.11.017
  8. Roehl KA, Antenor JA, Catalona WJ. Serial biopsy results in prostate cancer screening study. J Urol. 2002;167(6):2435-39. doi: 10.1016/S0022-5347(05)64999-3.
  9. Zhang M, Milot L, Khalvati F, et al. Value of Increasing Biopsy Cores per Target with Cognitive MRI-targeted Transrectal US Prostate Biopsy. Radiology. 2019;291:83. doi: 10.1148/radiol.2019180712. Epub 2019 Jan 29.
  10. Lu AJ, Syed JS, Ghabili K, et al. Role of Core Number and Location in Targeted Magnetic Resonance ImagingUltrasound Fusion Prostate Biopsy. Eur Urol. 2019;76:14. doi: 10.1016/j.eururo.2019.04.008. Epub 2019 Apr 30.
  11. Hofman MS, Lawrentschuk N, Francis RJ, et al. Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study. Lancet. 2020;395:1208. doi: 10.1016/S0140-6736(20)30314-7. Epub 2020 Mar 22
  12. Emmet L, Buteau J, Papa N, et al. The additive diagnostic value of prostate-specific membrane antigen positron emission tomography computed tomography to multiparametric magnetic resonance imaging triage in the diagnosis of prostate cancer (PRIMARY): a prospective multicentre study. Eur Urol. 2021;80:682:689. doi: 10.1016/j.eururo.2021.08.002
  13. Meissner VH, Rauscher I, Schwamborn K, et al. Radical prostatectomy without prior biopsy following multiparametric magnetic resonance imaging and prostate-specific membrane antigen positron emission tomography. Eur Urol. 2022;82:156–60. doi: 10.1016/j.eururo.2021.08.002
  14. Nakata S, Nakano K, Takahashi H, et al. A case of prostate cancer diagnosed pathologically by bone metastatic site biopsy. Nippon Hinyokika Gakkai Zasshi. 2005;96(4):507–510. doi: 10.5980/jpnjurol1989.96.507.
  15. Fukumoto R, Soda T, Uehara M, et al. A case of prostate cancer diagnosed by lymphadenectomy. Hinyokika Kiyo. 2012;58(10):557–560. PMID: 23235279
  16. Ueda Y, Higuchii Y, Hashimoto T, et al. Prostate cancer diagnosed through the biopsy of the bone metastatic lesion; a case report. Hinyokika Kiyo. 2007 May;53(5):327-30. Japanese. PMID: 17561720.
  17. Iwamura H, Hatakeyama S, Tanaka Y, et al. A case of metastatic cancer with markedly elevated PSA level that was not detected by repeat prostate biopsy. BMC Res Notes. 2014 Jan 29;7:64. doi: 10.1186/1756-0500-7-64.