Vol. 24 No. 1 (2025)
Literature Review

Trends and Insights into Glymphatic System Research and Alzheimer's Disease: A Bibliometric Analysis from 2014 to 2023

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  • Raphael L. Olegário,
  • Luciana Lilian L. Martini,
  • Priscila C. Teixeira,
  • Diógenes Diego de C. Bispo,
  • Felipe von Glehn,
  • Otávio T. Nóbrega,
  • Einstein Francisco Camargo
Raphael L. Olegário
Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília. Brasília, DF, Brasil.
Bio
Luciana Lilian L. Martini
Departamento de Clínica Médica, Centro de Medicina Geriátrica, Hospital Universitário de Brasília. Brasília, DF, Brasil.
Priscila C. Teixeira
Departamento de Clínica Médica, Centro de Medicina Geriátrica, Hospital Universitário de Brasília. Brasília, DF, Brasil.
Diógenes Diego de C. Bispo
Unidade de Imagem Diagnóstica, Hospital Universitário de Brasília. Brasília, DF, Brasil.
Felipe von Glehn
Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília. Brasília, DF, Brasil.
Bio
Otávio T. Nóbrega
Bio
Einstein Francisco Camargo
Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília. Brasília, DF, Brasil.
Bio
DOI: https://doi.org/10.12957/bjhbs.2025.93438

Published 2025-08-08

Keywords

  • Glymphatic System,
  • Alzheimer's Disease,
  • Bibliometric Analysis,
  • Neuroscience,
  • Neuroimaging

How to Cite

1.
L. Olegário R, Lilian L. Martini L, C. Teixeira P, Diego de C. Bispo D, von Glehn F, T. Nóbrega O, Francisco Camargo E. Trends and Insights into Glymphatic System Research and Alzheimer’s Disease: A Bibliometric Analysis from 2014 to 2023. BJHBS [Internet]. 2025 Aug. 8 [cited 2025 Oct. 10];24(1). Available from: https://bjhbs.hupe.uerj.br/bjhbs/article/view/209

Copyright (c) 2025 Brazilian Journal of Health and Biomedical Sciences

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Abstract

Introduction: Over the past decade, research on the Glymphatic System has gained increasing attention within the scientific community. This system, initially explored through animal models and Magnetic Resonance Imaging tracer-based studies, holds potential implications for understanding neurodegenerative diseases, notably Alzheimer's Disease. However, there is a lack of bibliometric analysis of research related to Glymphatic System and Alzheimer's Disease. Objective: Our study aimed to conduct a comprehensive analysis of the existing literature on Glymphatic System research, with a particular focus on its intersection with investigations into Alzheimer's Disease pathology. By synthesizing available data, we sought to identify trends, gaps, and potential avenues for future research and collaboration in this evolving field. Methods and Resources: We utilized statistical techniques to analyze data obtained from the Web of Science Core Collection database. Our methodology encompassed various aspects, including publication frequency, geographical distribution, citation networks, and thematic analysis of authors' keywords. Results and discussion: Our analysis encompassed a wide range of publications spanning the last decade, revealing a gradual increase in research output over time. Notably, we observed a significant level of international collaboration, underscoring the global nature of scientific inquiry in this domain. However, disparities in research capacity and collaboration were apparent, particularly among regions with limited resources. Conclusion: Our findings highlight the importance of continued interdisciplinary collaboration and exploration to advance our understanding of Glymphatic System function and its relevance to neurodegenerative disorders.

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References

  1. Lopes DM, Wells JA, Ma D, et al. Glymphatic inhibition exacerbates tau propagation in an Alzheimer’s disease model. Alzheimers Res Ther 2024; 16: 71.
  2. He X, Liu D, Zhang Q, et al. Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice. Front Mol Neurosci; 10. Epub ahead of print 2017. DOI: 10.3389/fnmol.2017.00144.
  3. Iliff JJ, Wang M, Liao Y, et al. A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β. Sci Transl Med 2012; 4: 147ra111-147ra111.
  4. Peng W, Achariyar TM, Li B, et al. Suppression of glymphatic fluid transport in a mouse model of Alzheimer’s disease. Neurobiol Dis 2016; 93: 215–225.
  5. Taoka T, Jost G, Frenzel T, et al. Impact of the Glymphatic System on the Kinetic and Distribution of Gadodiamide in the Rat Brain. Invest Radiol 2018; 53: 529–534.
  6. Huang S-Y, Zhang Y-R, Guo Y, et al. Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer’s disease. Alzheimer’s & Dementia; n/a. Epub ahead of print 19 March 2024. DOI: https://doi.org/10.1002/alz.13789.
  7. Bohr T, Hjorth PG, Holst SC, et al. The glymphatic system: Current understanding and modeling. iScience 2022; 25: 104987.
  8. Mestre H, Mori Y, Nedergaard M. The Brain’s Glymphatic System: Current Controversies. Trends Neurosci 2020; 43: 458–466.
  9. Naganawa S, Taoka T, Ito R, et al. The Glymphatic System in Humans: Investigations With Magnetic Resonance Imaging. Invest Radiol; 59, https://journals.lww.com/investigativeradiology/fulltext/2024/01000/the_glymphatic_system_in_humans__investigations.1.aspx (2024).
  10. Kiani L. Neuronal activity drives glymphatic waste clearance. Nat Rev Neurol 2024; 20: 255–255.
  11. Nedergaard M, Goldman SA. Glymphatic failure as a final common pathway to dementia. Science (1979) 2020; 370: 50–56.
  12. Reeves BC, Karimy JK, Kundishora AJ, et al. Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus. Trends Mol Med 2020; 26: 285–295.
  13. Karran E, Mercken M, Strooper B De. The amyloid cascade hypothesis for Alzheimer’s disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov 2011; 10: 698–712.
  14. Buccellato FR, D’Anca M, Serpente M, et al. The Role of Glymphatic System in Alzheimer’s and Parkinson’s Disease Pathogenesis. Biomedicines; 10. Epub ahead of print 2022. DOI: 10.3390/biomedicines10092261.
  15. Iliff JJ, Wang M, Liao Y, et al. A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β. Sci Transl Med 2012; 4: 147ra111-147ra111.
  16. Yang G, Deng N, Liu Y, et al. Evaluation of Glymphatic System Using Diffusion MR Technique in T2DM Cases. Front Hum Neurosci; 14. Epub ahead of print 2020. DOI: 10.3389/fnhum.2020.00300.
  17. Butler T, Zhou L, Ozsahin I, et al. Glymphatic clearance estimated using diffusion tensor imaging along perivascular spaces is reduced after traumatic brain injury and correlates with plasma neurofilament light, a biomarker of injury severity. Brain Commun 2023; 5: fcad134.
  18. Hou C, Ren W, Wang B, et al. A bibliometric and knowledge-map analysis of the glymphatic system from 2012 to 2022. Front Mol Neurosci; 16. Epub ahead of print 2023. DOI: 10.3389/fnmol.2023.1148179.
  19. Aria M, Cuccurullo C. bibliometrix : An R-tool for comprehensive science mapping analysis. J Informetr 2017; 11: 959–975.
  20. R Core Team. RStudio: Integrated Development for R.
  21. Gao Y, Liu K, Zhu J. Glymphatic system: an emerging therapeutic approach for neurological disorders. Front Mol Neurosci; 16. Epub ahead of print 2023. DOI: 10.3389/fnmol.2023.1138769.
  22. Boyd ED, Kaur J, Ding G, et al. Clinical magnetic resonance imaging evaluation of glymphatic function. NMR Biomed. Epub ahead of print 11 March 2024. DOI: 10.1002/nbm.5132.
  23. van Osch MJP, Wåhlin A, Scheyhing P, et al. Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood. NMR Biomed. Epub ahead of print 18 April 2024. DOI: 10.1002/nbm.5159.
  24. Lee MK, Cho SJ, Bae YJ, et al. MRI-Based Demonstration of the Normal Glymphatic System in a Human Population: A Systematic Review. Front Neurol; 13. Epub ahead of print 2022. DOI: 10.3389/fneur.2022.827398.
  25. Akinremi TO. Research collaboration with low resource countries: overcoming the challenges. Infect Agent Cancer 2011; 6: S3.
  26. Szlufik S, Kopeć K, Szleszkowski S, et al. Glymphatic System Pathology and Neuroinflammation as Two Risk Factors of Neurodegeneration. Cells; 13. Epub ahead of print 2024. DOI: 10.3390/cells13030286.
  27. Buccellato FR, D’Anca M, Serpente M, et al. The Role of Glymphatic System in Alzheimer’s and Parkinson’s Disease Pathogenesis. Biomedicines 2022; 10: 2261.
  28. DeTure MA, Dickson DW. The neuropathological diagnosis of Alzheimer’s disease. Mol Neurodegener 2019; 14: 32.
  29. Ding Z, Fan X, Zhang Y, et al. The glymphatic system: a new perspective on brain diseases. Front Aging Neurosci; 15, https://www.frontiersin.org/articles/10.3389/fnagi.2023.1179988 (2023).
  30. Voumvourakis KI, Sideri E, Papadimitropoulos GN, et al. The Dynamic Relationship between the Glymphatic System, Aging, Memory, and Sleep. Biomedicines 2023; 11: 2092.
  31. Nedergaard M, Goldman SA. Glymphatic failure as a final common pathway to dementia. Science (1979) 2020; 370: 50–56.
  32. Almondes KM de, Costa MV, Malloy-Diniz LF, et al. Insomnia and risk of dementia in older adults: Systematic review and meta-analysis. J Psychiatr Res 2016; 77: 109–115.
  33. Benca R, Herring WJ, Khandker R, et al. Burden of Insomnia and Sleep Disturbances and the Impact of Sleep Treatments in Patients with Probable or Possible Alzheimer’s Disease: A Structured Literature Review. Journal of Alzheimer’s Disease 2022; 86: 83–109.
  34. Reeves BC, Karimy JK, Kundishora AJ, et al. Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus. Trends Mol Med 2020; 26: 285–295.
  35. Roh JH, Huang Y, Bero AW, et al. Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology. Sci Transl Med; 4. Epub ahead of print 5 September 2012. DOI: 10.1126/scitranslmed.3004291.
  36. Shokri-Kojori E, Wang G-J, Wiers CE, et al. β-Amyloid accumulation in the human brain after one night of sleep deprivation. Proceedings of the National Academy of Sciences 2018; 115: 4483–4488.
  37. Rothman SM, Herdener N, Frankola KA, et al. Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer’s disease. Brain Res 2013; 1529: 200–208.
  38. Moser E, Stadlbauer A, Windischberger C, et al. Magnetic resonance imaging methodology. Eur J Nucl Med Mol Imaging 2009; 36: 30–41.
  39. Taoka T, Naganawa S. Glymphatic imaging using MRI. Journal of Magnetic Resonance Imaging 2020; 51: 11–24.
  40. Weintraub S. Neuropsychological Assessment in Dementia Diagnosis. CONTINUUM: Lifelong Learning in Neurology 2022; 28: 781–799.
  41. Boller F, Barba GD. Neuropsychological tests in Alzheimer’s disease. Aging Clin Exp Res 2001; 13: 210–220.