Vol. 20 No. 2 (2021)
Original Articles

Multiresistance and endemic status of Corynebacterium striatum associated with nosocomial infections: a critical situation in Intensive Care Units and varied wards of a tertiary care hospital, Rio de Janeiro metropolitan area, Brazil

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  • Cecília Maria F. Silva,
  • Higor F. Mota,
  • Felipe de O. Cabra,
  • Yuri V. Farias,
  • Stefany M. Dimas,
  • Giorgio S. de Santana,
  • Letícia N. M. de Gusmão,
  • Bárbara A. Nogueira,
  • Juliana N. Ramos,
  • Monica Cristina de Souza,
  • Robson de S. Leão,
  • Marcus Vinícius G. de Oliveira,
  • Louisy S. dos Santos,
  • Ana Luíza Mattos-Guaraldi,
  • Cassius de Souza
DOI: https://doi.org/10.12957/bjhbs.2021.63963

Published 2022-01-04

Keywords

  • Corynebacterium striatum,
  • Multidrug resistance,
  • Nosocomial infections,
  • Virulence,
  • Endemic

How to Cite

1.
F. Silva CM, F. Mota H, de O. Cabra F, V. Farias Y, M. Dimas S, S. de Santana G, N. M. de Gusmão L, A. Nogueira B, N. Ramos J, de Souza MC, de S. Leão R, G. de Oliveira MV, S. dos Santos L, Mattos-Guaraldi AL, de Souza C. Multiresistance and endemic status of Corynebacterium striatum associated with nosocomial infections: a critical situation in Intensive Care Units and varied wards of a tertiary care hospital, Rio de Janeiro metropolitan area, Brazil. BJHBS [Internet]. 2022 Jan. 4 [cited 2024 Sep. 28];20(2):114-28. Available from: https://bjhbs.hupe.uerj.br/bjhbs/article/view/34

Copyright (c) 2021 Brazilian Journal of Health and Biomedical Sciences

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Abstract

Nowadays, Corynebacterium striatum has been reported as etiologic agent of mild to severe hospital-acquired infections, including patients undergoing endotracheal intubation with fatal outcome. A continuous survey of infections due multi-drug-resistant (MDR) C. striatum in South American countries remains necessary. This retrospective and prospective study aimed to analyze clinical-microbiological features of C. stri-atum clinical isolates from patients attended at a Brazilian tertiary care hospital, during a nine-year period. C. striatum strains (n=130) were isolated from infected patients attended at twenty nosocomial wards, mainly of tracheal aspirate (n=53) and blood and/or intravenous catheter (n=21/n=13). Notably, original cases of nosocomial infections due to C. striatum were verified in children making use of invasive devices, includ-ing one fatal neonatal case, in addition to a fatal respiratory infection in patient with cystic fibrosis, as well as urinary tract infections of kidney transplant recipients. Most of C. striatum strains expressed MDR profiles (88.46%). Emergence of vancomycin (1.90%) and linezolid (7.41%) resistance was verified among MDR and non-MDR-strains. In conclusion, endemic condition with wide dissemination among hospital wards of varied types of infections due to MDR and non-MDR C. striatum strains expressing heterogenic virulence potential and genetic features may occur in hospital units.

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