Vol. 19 No. 2 (2020)
Literature Review

Pulmonary and central nervous system infiltration of chronic lymphocytic leukemia with concomitant diffuse large B-cell lymphoma: Case report and review of literature

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  • Saulo F. D. Batista,
  • Karina V. de Melo,
  • Patricia Horn,
  • Vinicius da C. Lisboa,
  • Ana Sheila Cypriano,
  • Andrea Pires,
  • Marilza de M. Ribeiro-Carvalho,
  • Fábio Santiago,
  • Maria Helena F. O. de Souza
DOI: https://doi.org/10.12957/bjhbs.2020.59716

Published 2021-01-04

Keywords

  • Chronic lymphoid leukemia (CLL),
  • Diffuse large B-cell lymphoma (DLBCL),
  • Central Nervous System infiltra-tion,
  • Pulmonary infiltration

How to Cite

1.
F. D. Batista S, V. de Melo K, Horn P, da C. Lisboa V, Cypriano AS, Pires A, de M. Ribeiro-Carvalho M, Santiago F, F. O. de Souza MH. Pulmonary and central nervous system infiltration of chronic lymphocytic leukemia with concomitant diffuse large B-cell lymphoma: Case report and review of literature. BJHBS [Internet]. 2021 Jan. 4 [cited 2025 Jan. 22];19(2):124-9. Available from: https://bjhbs.hupe.uerj.br/bjhbs/article/view/78

Copyright (c) 2020 Brazilian Journal of Health and Biomedical Sciences

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Abstract

Introduction: Diffuse large B-cell lymphoma (DLBCL) and chronic lymphoid leukemia (CLL) are lymphoproliferative diseases of B lymphocytes. Objective: To describe the con-comitance of diseases with pulmonary and CNS involvement. Clinical case: A 67-year-old patient with DLBCL and CLL obtained partial remission of the diseases after six cycles of standard combined chemotherapy. Relapse of CLL (del17p; TP53+) occurred after 22 months, becoming refractory to a new treatment. Monoclonal B lymphocyte infiltration was found in the cerebrospinal fluid and bronchoalveolar lavage, leading to death due to respiratory failure. Conclusion: The unfavorable outcome shows a rare and serious complication in the concomitance of these diseases.

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