Vol. 18 No. 2 (2019)
Original Articles

Diabetic pneumopathy: A study of induced sputum and pulmonary function in patients with type 2 diabetes mellitus

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  • Rogério M. Bártholo,
  • Elizabeth Bessa,
  • Thiago P. Bártholo,
  • Cláudia Henrique da Costa,
  • Agnaldo José Lopes,
  • Rogério Rufino
Rogério M. Bártholo
Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.
Elizabeth Bessa
Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.
Thiago P. Bártholo
Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.
Cláudia Henrique da Costa
Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.
Agnaldo José Lopes
Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.
Rogério Rufino
Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.
DOI: https://doi.org/10.12957/bjhbs.2019.53509

Published 2020-01-03

Keywords

  • Diabetes mellitus type 2,
  • Induced sputum,
  • Lymphocytes

How to Cite

1.
Rogério M. Bártholo, Elizabeth Bessa, Thiago P. Bártholo, Cláudia Henrique da Costa, Agnaldo José Lopes, Rogério Rufino. Diabetic pneumopathy: A study of induced sputum and pulmonary function in patients with type 2 diabetes mellitus. BJHBS [Internet]. 2020 Jan. 3 [cited 2025 Jan. 22];18(2):144-50. Available from: https://bjhbs.hupe.uerj.br/bjhbs/article/view/123

Copyright (c) 2020 Brazilian Journal of Health and Biomedical Sciences

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Abstract

Objective: To evaluate the cellularity, and albumin and interleukin (IL)-1 levels in induced sputum (IS), and to determine respiratory function parameters in patients with type 2 diabetes mellitus (DM2). Design: A cross-section study in type 2 diabetes mellitus. Participants: Patients with type 2 diabetes mellitus and healthy people. Methods: Patients in both groups had normal chest x-ray findings. Exclusion criteria for both groups were: the presence of current pulmonary disease or sequelae, smoking, respiratory atopy, or respiratory infection in the past 3 months. The study consisted of two sub-studies. In sub-study 1 (SS1), measurements of pulmonary volume and flow, and diffusion capacity for carbon monoxide (DLCO) were performed. In sub-study 2 (SS2), analysis of cellularity, albumin, and IL-1 in IS was performed. Results: In all, 60 patients (45 women, 75%) with DM2 with a mean age of 59.52 years (SD, 9.03) were included in SS1. The DM2 group included 8 patients with airway obstruction (13.33%) without reversibility with bronchodilators, and 9 with restrictive disease (15.00 %) (p = 0.026). The DLCO was reduced in 17 patients (28.33%) in the DM2 group. In the control group, all individuals had values within the reference intervals. Lymphocytosis was found in the IS of patients with DM2 (p = 0.028). The levels of sputum albumin showed no statistical difference between the two groups. Conclusion: Our findings indicate the presence of pulmonary impairment in DM2, characterized by changes in the respiratory function and a lymphocytosis in IS.

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