Vol. 23 No. 1 (2024)
Literature Review

Piperacillin-Tazobactam: update for clinical use

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  • Alice Rezende Correa e Castro Costa,
  • Andréia Patrícia Gomes,
  • Eduardo Vinícius Vieira Varejão,
  • Romario Brunes Will,
  • Walter Tavares,
  • Luiz Alberto Santana,
  • Rodrigo Siqueira-Batista
Rodrigo Siqueira-Batista
Universidade Federal de Viçosa
DOI: https://doi.org/10.12957/bjhbs.2024.85197

Published 2024-08-21

Keywords

  • Anti-Bacterial Agents; Piperacillin, Tazobactam Drug Combination; beta-Lactams

How to Cite

1.
Rezende Correa e Castro Costa A, Gomes AP, Vieira Varejão EV, Will RB, Tavares W, Santana LA, Siqueira-Batista R. Piperacillin-Tazobactam: update for clinical use. BJHBS [Internet]. 2024 Aug. 21 [cited 2024 Dec. 3];23(1). Available from: https://bjhbs.hupe.uerj.br/bjhbs/article/view/165

Copyright (c) 2024 Brazilian Journal of Health and Biomedical Sciences

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Abstract

Introduction: Piperacillin-tazobactam, a broad-spectrum penicillin, represents a crucial option in the treatment of infections, especially in critically ill patients who exhibit high rates of resistance to various antimicrobial agents. It is of paramount importance to understand this medication and its updates regarding its clinical use to inform precise therapeutic choices aimed at optimizing patient care. Objective: To describe the main pharmacological and therapeutic aspects of piperacillin-tazobactam, highlighting its clinical application and updates related to its use. Methods: A narrative review of the literature was conducted to provide an update on the most relevant aspects related to piperacillin-tazobactam, including (1) a brief history; (2) chemical structure; (3) mechanism of action; (4) resistance mechanisms; (5) spectrum; (6) major clinical uses; and (7) adverse effects. Results: The safe use of piperacillin-tazobactam necessitates rapid testing for antimicrobial resistance patterns, discouraging its empirical use in cases of ESBL-producing microorganisms. In patients undergoing renal replacement therapy, it is crucial to establish antibiotic goals promptly. For critically ill patients, monitoring pharmacodynamic and pharmacokinetic variability is essential. Conclusion: Piperacillin-tazobactam remains a vital drug in the management of critically ill patients, requiring constant updates. Furthermore, there is a need for further studies, especially concerning its continuous use and the selection of alternatives to carbapenem-resistant medications.

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