Vol. 20 No. 2 (2021)
Literature Review

Relationship between vitamin D and cancer: A narrative review

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  • Luciana L. Alves,
  • Luiza Torres-Nunes,
  • Marcella de Lucena-Machado,
  • Yanca Maiara A. de Azevedo,
  • Danúbia da C. de Sá-Caputo,
  • Mario Bernardo-Filho
DOI: https://doi.org/10.12957/bjhbs.2021.63969

Published 2022-01-04

Keywords

  • Vitamin D,
  • Cancer,
  • Narrative review,
  • Cancer prevention,
  • Health problems

How to Cite

1.
L. Alves L, Torres-Nunes L, de Lucena-Machado M, A. de Azevedo YM, da C. de Sá-Caputo D, Bernardo-Filho M. Relationship between vitamin D and cancer: A narrative review. BJHBS [Internet]. 2022 Jan. 4 [cited 2024 Nov. 21];20(2):161-6. Available from: https://bjhbs.hupe.uerj.br/bjhbs/article/view/39

Copyright (c) 2021 Brazilian Journal of Health and Biomedical Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Abstract

Introduction: Vitamin D is involved in several human me-tabolism pathways, both in classic pathway, which involves the calcium and phosphorus metabolism, and in non-classic pathways, which are related to several types of diseases, includ-ing diseases related to muscles; kidneys; cardiovascular system; immune system; some types of cancer; diabetes; and pregnan-cy. Objectives: As cancer is one of the main health problems in the world and knowing that it is one of the non-classic effects related to vitamin D, the current narrative review aimed to verify the relevance of vitamin D has on the types of cancer. Methods: The bibliographic research was performed in data-bases Pubmed, Scopus and PEDro on June 16, 2020, using the keywords “vitamin D”, “cancer” and “non-classic”. Only articles since the year 2000 were included. Thirty-one articles were analyzed relating vitamin D to colon/rectum cancer, breast cancer, prostate cancer, lung cancer, ovarian cancer, melanoma and other types of skin cancer, and gastric cancer. Results: All studies have shown a relationship between vitamin D and the incidence of cancer in the human body, however, there are peculiarities regarding the concentration levels in each organ. Even with conflicting results, in general, vitamin D has shown to be promise in the prevention of several types of cancer.

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